Prelu-2

Generic Name: phendimetrazine (Oral route)

fen-dye-MET-ra-zeen TAR-trate

Commonly used brand name(s)

In the U.S.

• Bontril


• Bontril PDM


• Bontril Slow-Release


• Melfiat


• Obezine


• Phendiet


• Phendiet-105


• Prelu-2

Available Dosage Forms:

• Tablet


• Capsule


• Capsule, Extended Release

Therapeutic Class: Appetite Suppressant, Centrally Acting

Chemical Class: Phendimetrazine

Uses For Prelu-2

Phendimetrazine is used as part of a short-term plan, along with a low calorie diet, for weight reduction. It is used in obese patients who have not been able to lose weight with diet and exercise alone. Phendimetrazine belongs to the group of medicines known as appetite suppressants.

This medicine is available only with your doctor's prescription.

Before Using Prelu-2

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of phendimetrazine tablets in the pediatric population. Safety and efficacy have not been established.

Use of phendimetrazine slow-release capsules is not recommended in children younger than 12 years of age.

Geriatric

No information is available on the relationship of age to the effects of phendimetrazine in geriatric patients.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Brofaromine


• Clorgyline


• Furazolidone


• Iproniazid


• Isocarboxazid


• Lazabemide


• Linezolid


• Moclobemide


• Nialamide


• Pargyline


• Phenelzine


• Procarbazine


• Rasagiline


• Selegiline


• Sibutramine


• Toloxatone


• Tranylcypromine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Agitated state or


• Arteriosclerosis (hardening of the arteries), advanced or


• Drug abuse or dependence, history of or


• Glaucoma or


• Heart problems (e.g., heart murmur, valvular heart disease) or


• Hypertension (high blood pressure), moderate to severe or


• Hyperthyroidism (overactive thyroid)—Should not be used in patients with these conditions.

• Hypertension (high blood pressure), mild—Use with caution. May make these conditions worse.

Proper Use of phendimetrazine

This section provides information on the proper use of a number of products that contain phendimetrazine. It may not be specific to Prelu-2. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may become habit-forming (causing mental or physical dependence).

This medicine is available in two forms: slow-release capsules and tablets. Ask your doctor which dosage form is right for you.

Carefully follow your doctor's instructions for a reduced-calorie diet plan and regular exercise. Talk with your doctor before starting any exercise program.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For treatment of obesity:
  
  • For oral dosage form (slow-release capsules):
    
    • Adults and teenagers—One capsule or 105 milligrams (mg) once a day, taken 30 to 60 minutes before the morning meal.
    
    
    • Children younger than 12 years of age—Use is not recommended.
    
    
  
  
  • For oral dosage form (tablets):
    
    • Adults—One tablet or 35 milligrams (mg) two or three times a day, taken one hour before meals. Your doctor may adjust your dose as needed. However, the dose is usually not more than 2 tablets three times a day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Prelu-2

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and does not cause any unwanted effects.

Do not use phendimetrazine if you are also using similar medicines such as benzphetamine, diethylpropion, mazindol, phentermine, Didrex®, or Suprenza™. Also, do not use this medicine if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within the past 14 days. Using these medicines together may cause serious unwanted effects.

Make sure your doctor knows if you are pregnant or planning to become pregnant before using this medicine.

This medicine may be habit-forming. If you think this medicine is not working properly after you have taken it for a few weeks, do not increase the dose. Instead, check with your doctor.

Stop using this medicine and check with your doctor right away if you notice a decrease in your ability to exercise, if you faint, or if you have chest pain, swelling of your feet or lower legs, or trouble with breathing. These may be symptoms of a very serious heart or lung problem.

This medicine may cause some people to become dizzy, lightheaded, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

For diabetic patients: This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription and nonprescription (over-the-counter) medicines, dietary supplements, herbal remedies, or medicines for appetite control, asthma, colds, cough, hay fever, and sinus problems.

Prelu-2 Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

• Seeing, hearing, or feeling things that are not there


• severe mental changes

Incidence not known

• Anxiety


• burning while urinating


• difficult or painful urination


• dizziness


• dry mouth


• fast, irregular, pounding, or racing heartbeat or pulse


• feeling of warmth


• headache


• hyperventilation


• increased need to urinate


• irritability


• nervousness


• numbness or tingling in the arms or legs


• passing urine more often


• redness of the face, neck, arms, and occasionally, upper chest


• restlessness


• shakiness in the legs, arms, hands, or feet


• shortness of breath


• sweating


• trembling or shaking of the hands or feet


• trouble sleeping


• trouble thinking, speaking, or walking


• weakness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Abdominal or stomach cramps


• blurred vision


• change in consciousness


• convulsions


• diarrhea


• discouragement


• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


• fainting


• fast, slow, or irregular heartbeat


• feeling sad or empty


• lack of appetite


• lightheadedness


• loss of consciousness


• loss of interest or pleasure


• nausea


• overactive reflexes


• panic


• physical attempt to injure


• pounding in the ears


• rapid breathing


• sweating


• tiredness


• trouble concentrating


• unusual tiredness or weakness


• violent actions


• vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Decreased interest in sexual intercourse


• difficulty having a bowel movement (stool)


• inability to have or keep an erection


• increased in sexual ability, desire, drive, or performance


• increased interest in sexual intercourse


• loss in sexual ability, desire, drive, or performance


• sleeplessness


• stomach pain


• unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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Pharmaton Capsules

1. Name Of The Medicinal Product

Pharmaton Vitality Capsules

2. Qualitative And Quantitative Composition

Each capsule contains:

Active Ingredients		Declaration per capsule
G115 Panax Ginseng extract [dry extract ethanolic 40%: 1.3 – 3:1]		40.0	mg
Vitamin A Palmitate	(Vit.A)	2667	IU
Colecalciferol	(Vit.D3)	200	IU
D,L-α-Tocopherol acetate	(Vit.E)	10	mg
Thiamine mononitrate	(Vit.B1)	1.4	mg
Riboflavin	(Vit.B2)	1.6	mg
Pyridoxine hydrochloride	(Vit.B6)	2.0	mg
Cyanocobalamine	(Vit.B12)	1.0	mcg
Biotin		150.0	mcg
Nicotinamide		18.0	mg
Ascorbic acid		60.0	mg
Folic acid		0.1	mg
Copper(II) sulphate dried	(Cu:2.0 mg)	5.6	mg
Sodium selenite, dried	(Se:50.0 mcg)	111.0	mcg
Magnesium sulphate, dried	(Mg:10.0 mg)	71.0	mg
Iron(II) sulphate, dried	(Fe:10.0 mg)	33.0	mg
Zinc sulphate, monohydrate	(Zn:1.0 mg)	2.75	mg
Dibasic calcium phosphate, anhydrous	(Ca:100.0 mg)	340.0	mg
Lecithin (containing choline, inositol, linoleic acid, linolenic acid)		100.0	mg

3. Pharmaceutical Form

Soft gelatin capsules for oral use.

4. Clinical Particulars

4.1 Therapeutic Indications

Pharmaton Vitality Capsules contain vitamins, minerals and standardised Ginseng Extract G115 in amounts which suit the body's daily requirements.

The capsules are indicated for relief of temporary periods of:

States of exhaustion (e.g. caused by stress), tiredness, feeling of weakness, vitality deficiency.

Prevention and treatment of symptoms caused by ill-balanced or deficient nutrition.

4.2 Posology And Method Of Administration

For situations of short term tiredness and exhaustion, Pharmaton Vitality Capsules are recommended for 4 weeks. If symptoms have not shown any improvement after 4 weeks, consult a doctor. Pharmaton Vitality Capsules may be taken for periods of up to 12 weeks. For longer term use consult a doctor.

Adults :	The recommended daily dosage is one capsule per day .
	The capsule should preferably be taken in the morning with food.
Children:	Not recommended for use in children.
Elderly:	There are no special dosage recommendations for the elderly.

4.3 Contraindications

Pharmaton Vitality Capsules are contraindicated in patients with disturbances of calcium (e.g. hypercalcaemia and hypercalciuria), hypervitaminosis A or D, renal insufficiency, concomitant retinoid (e.g. for acne) or vitamin D therapy, haemochromatosis, iron overload syndrome and in patients with known hypersensitivity to any of the ingredients in the product.

Pharmaton Vitality Capsules contain arachis oil (peanut oil) and should not be taken by patients known to be allergic to peanut. As there is a possible relationship between allergy to peanut and allergy to soya, patients with soya allergy should also avoid Pharmaton Vitality Capsules.

4.4 Special Warnings And Precautions For Use

Patients with a family history of haemochromatosis should seek medical advice before taking Pharmaton Vitality Capsules.

An allowance should be made for vitamins or minerals obtained from other sources.

In states of exhaustion (e.g. caused by stress), clinical trials have shown that improvement starts usually within 4 weeks of treatment. If symptoms have not shown any improvement during that time, or you are concerned, please consult your doctor.

The label will state “Important warning: Contains iron. Keep out of the reach and sight of children, as overdose may be fatal”. This will appear on the labelling within a rectangle in which there is no other information.

Patients taking warfarin (or other coumarin anticoagulants) should have increased monitoring of their INR levels when starting or stopping treatment with ginseng containing products.

Each capsule contains a small amount of lactose (26 mg). Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Panax ginseng may reduce the effect of warfarin (or other coumarin anticoagulants).

4.6 Pregnancy And Lactation

Reproduction studies with animals using the standardized Panax ginseng extract G115 Pharmaton showed no adverse effects on fertility, nor any teratogenic effects. However, controlled studies with pregnant women are not available.

Controlled studies with women using multivitamin-mineral preparations at the usual dosage during the course of the first trimester resulted in no fetal risks. There are no signs indicating a risk if this type of preparation is taken during the second and third trimesters, and the probability of injuring the fetus appears to be very low.

Large doses of vitamin A (10,000 IU per day) have been found to be teratogenic if administered during the first trimester of pregnancy. Vitamin D given during the last trimester of pregnancy may cause hypercalcaemia in infants. As with many other medicines an assessment of benefits versus risks should be made before this product is administered during this period.

Pharmaton Vitality Capsules should not be taken during pregnancy or lactation.

4.7 Effects On Ability To Drive And Use Machines

None known

4.8 Undesirable Effects

Cases of headache, dizziness, insomnia, gastrointestinal reactions (such as nausea, stomach pain, vomiting and diarrhoea) and hypersensitivity reactions (such as rash, pruritus) have been observed.

4.9 Overdose

Nervousness may occur following an overdose of the product.

The toxicity of the product in large overdoses is caused by the toxicity of the liposoluble vitamins A and D. A safe dose for both vitamins is considered to be 5-10 x RDA (each capsule contains the EU %RDA for vitamins A and D).

Prolonged supply of larger amounts (40-55 x RDA for Vitamin A; 10-25 x RDA for Vitamin D) can cause symptoms of chronic toxicity. Acute toxic symptoms are only seen at even higher doses.

Iron: Severe acute toxicity in man has been reported from doses of iron ranging from 12-1500 x RDA (each capsule contains the UK %RDA for iron). Most incidents of acute iron toxicity have resulted from accidental oral ingestion of iron pills by children. Longer-term doses of iron up to 6-7 x RDA have been reported to have no toxic effect.

Symptoms: Initial symptoms include nausea, vomiting, diarrhoea, abdominal pain, haematemesis, rectal bleeding, lethargy and circulatory collapse. Hyperglycaemia and metabolic acidosis may also occur.

Treatment: To minimise or prevent further absorption of the medication, as follows:

Induce vomiting e.g. by administration of an emetic.

Gastric lavage with desferrioxamine solution (2g/l). Then desferrioxamine (5 - 10g in 50-100ml water) should be introduced into the stomach to be retained.

Severe poisoning: Shock and/or coma with high iron levels (serum iron>90µmol/l in children,>142µmol/l in adults); immediate supportive measures plus i.v. infusion of desferrioxamine should be instituted.

Less severe poisoning: i.m. desferrioxamine is recommended (1g 4-6 hourly in children; 50mg/kg up to a maximum dose of 4g in adults).

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Pharmaton Vitality Capsules exert a stimulant effect at physical and psychological levels through the combined action of various substances on the basic metabolic processes.

The standardised ginseng extract G115 raises the general level of cellular activity, which is expressed by a pronounced increase in the physical and mental capacity.

In animal experiments, it caused a reduction of lactic acid concentration in muscles during exercise. An increase in the dopamine and noradrenaline content and a reduction in the serotonin content in the brain stem could be observed.

Vitamins, minerals and trace elements correct and prevent impairment of the cell metabolism in situations with increased demands. Low supply of vitamins, minerals, and trace elements may cause disturbances, such as debility, tiredness, decrease in vitality, reduced force of resistance, and decelerated convalescence. The composition and dosages of the preparation were chosen according to the European RDA-requirements for food supplements.

Choline, inositol, linoleic acid and linolenic acid, in the form of lecithin, improve energy output and lipid metabolism.

5.2 Pharmacokinetic Properties

Pharmacokinetic studies of Pharmaton Vitality Capsules have not been carried out, because of the complex composition of the product and the small quantities of the active ingredients contained. Moreover, these substances are well known.

Pharmacokinetic studies of the standardised ginseng extract G115 are not possible, because it is a complex extract. In the ginseng root more than 200 substances have been identified to date. Pharmacokinetic studies of individual purified ginsenosides have been carried out in various animal species:

Using radioactively labelled (¹⁴C) Ginsenoside Rgl, originated from the standardized Panax ginseng extract G115 Pharmaton, a bioavailability of 30% was determined in mice.

With intraperitoneal application, depending on the tested animal species and the Ginsenoside type, a half-life of between 27 minutes and 14.5 hours was measured.

5.3 Preclinical Safety Data

Acute toxicity

The oral LD₅₀ of the standardized Panax ginseng extract G115 Pharmaton is more than 5 g/kg of body weight in the mouse and the rat, and more than 2 g/kg in the mini-pig.

Reproduction toxicity

The effect of standardized Panax ginseng extract G115 Pharmaton on reproductive performance was studied in two generations of Sprague-Dawley rats. Animals of both sexes were fed either control diet or diet supplemented with the standardized Panax ginseng extract G115 Pharmaton at dose levels of 1.5, 5 or 15 mg/kg body weight/day. Parameters of reproduction and lactation in the treated groups were comparable to those of the controls for two generations of dams and pups. No treatment-related effects were seen in weekly body weights and food consumption, haematological and blood chemistry parameters, and ophthalmic, macroscopic and histopathological examinations.

Fetal toxicity

The standardized Panax ginseng extract G115 Pharmaton, administered to pregnant Wistar rats and pregnant New Zealand rabbits, caused no abnormality in the foetal development.

The rats were treated with 40 mg/kg/day from the 1st to the 15th day after mating.

The rabbits were treated with 20 mg/kg/day from the 7th to the 16th day after mating.

The fetuses were removed by caesarean section on the 21st day in the rats and on the 27th day in the rabbits.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Capsule:

Rapeseed oil, refined

Hard fat

Ethyl vanillin

Arachis oil (peanut oil)

Triglycerides, medium chain

Gelatin

Lactose monohydrate

Silica, colloidal anhydrous

Capsule shell:

Gelatin

Glycerol 85%

Iron oxide red (E172)

Iron oxide black (E172)

6.2 Incompatibilities

None stated.

6.3 Shelf Life

Glass bottle packs	3 years
Blister packs	2 years

6.4 Special Precautions For Storage

Do not store above 25°C. Keep the container tightly closed.

6.5 Nature And Contents Of Container

Brown glass bottles (hydrolytical class III, Ph.Eur) with pilfer proof aluminium caps (with rubber inserts) containing either 30, 40, 60, 90 or 100 capsules. Or Aluminium foil/polyvinylchloride/polyvinylidenchloride blister packs of 4, 30, 40, 60, 90 and 100 capsules.

Current Marketed Packs

Brown glass bottles (hydrolytical class m, Ph.Eur) with pilfer proof aluminium caps (with rubber inserts) containing either 30, 60, or 100 capsules.

6.6 Special Precautions For Disposal And Other Handling

None stated.

7. Marketing Authorisation Holder

Boehringer Ingelheim Limited (Self Medication Division)

Trading as Pharmaton Natural Health Products

Ellesfield Avenue

Bracknell

Berkshire

RG12 8YS

8. Marketing Authorisation Number(S)

PL 00015/0250

9. Date Of First Authorisation/Renewal Of The Authorisation

03/12/2008

10. Date Of Revision Of The Text

October 2009

calcitonin Parenteral

kal-si-TOE-nin

Uses For calcitonin

Calcitonin is used to treat Paget's disease of bone. It also may be used to prevent continuing bone loss in women with postmenopausal osteoporosis and to treat hypercalcemia (too much calcium in the blood). calcitonin may be used to treat other conditions as determined by your doctor.

calcitonin is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, calcitonin is used in certain patients with the following medical condition:

• Osteoporosis caused by hormone problems, certain drugs, and other causes

Before Using calcitonin

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on calcitonin have been done only in adult patients, and there is no specific information comparing the use of calcitonin in children with use in other age groups. Therefore, be sure to discuss with your doctor the use of calcitonin in children.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing the use of calcitonin in the elderly with use in other age groups, calcitonin is not expected to cause different side effects or problems in older people than it does in younger adults. Calcitonin is often used in elderly patients.

Pregnancy

Calcitonin has not been studied in pregnant women. However, in animal studies, calcitonin has been shown to lower the birth weight of the baby when the mother was given a dose of calcitonin many times the human dose.

Breast Feeding

Calcitonin has not been reported to cause problems in nursing babies. However, studies in animals have shown that calcitonin may decrease the flow of breast milk.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of calcitonin

Make certain your health care professional knows if your diet includes large amounts of calcium-containing foods and/or vitamin D-containing foods, such as milk or other dairy products. Calcium and vitamin D may cause the calcitonin to be less effective in treating a high blood calcium. Also let your health care professional know if you are on any special diet, such as low-sodium or low-sugar diet.

calcitonin is for injection only. If you will be giving yourself the injections, make sure you understand exactly how to give them, including how to fill the syringe before injection. If you have any questions about this, check with your doctor.

Use the calcitonin only when the contents of the syringe are clear and colorless. Do not use it if it looks grainy or discolored.

Dosing

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For calcitonin-human


• For injection dosage form:
  
  • For Paget's disease of bone:
    
    • Adults—To start, 500 micrograms (mcg) injected under the skin once a day. Your doctor may reduce your dose or increase the time between doses. Or, your doctor may give you a smaller dose to start and increase your dose over two weeks.
    
    
    • Children—Dose must be determined by your doctor.
    
    
  
  

• For calcitonin-salmon


• For injection dosage form:
  
  • For Paget's disease of bone:
    
    • Adults—To start, 100 Units injected into a muscle or under the skin once a day, once every other day, or three times a week. Your doctor may reduce your dose or increase the time between doses.
    
    
    • Children—Dose must be determined by your doctor.
    
    
  
  
  • For hypercalcemia (too much calcium in the blood):
    
    • Adults—To start, 4 Units per kilogram (kg) (1.8 Units per pound) of body weight injected into a muscle or under the skin every twelve hours. Your doctor may increase your dose or increase the time between doses.
    
    
    • Children—Dose must be determined by your doctor.
    
    
  
  
  • For postmenopausal osteoporosis:
    
    • Adults—100 Units injected into a muscle or under the skin once a day, once every other day, or three times a week. Or, your doctor may give you a smaller dose to start and increase your dose over two weeks.
    
    
    • Children—Dose must be determined by your doctor.
    
    
  
  

Missed Dose

Call your doctor or pharmacist for instructions.

If you miss a dose of calcitonin and your dosing schedule is:

• Two doses a day—If you remember within 2 hours of the missed dose, give it right away. Then go back to your regular dosing schedule. But if you do not remember the missed dose until later, skip it and go back to your regular dosing schedule. Do not double doses.


• One dose a day—Give the missed dose as soon as possible. Then go back to your regular dosing schedule. If you do not remember the missed dose until the next day, skip it and go back to your regular dosing schedule. Do not double doses.


• One dose every other day—;Give the missed dose as soon as possible if you remember it on the day it should be given. Then go back to your regular dosing schedule. If you do not remember the missed dose until the next day, give it at that time. Then skip a day and start your dosing schedule again.


• One dose three times a week—Give the missed dose the next day. Then set each injection back a day for the rest of the week. Go back to your regular Monday-Wednesday-Friday schedule the following week. Do not double doses.

If you have any questions about this, check with your doctor.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Store calcitonin-human at a temperature below 77 °F. Do not refrigerate. Use prepared solution within 6 hours.

Store calcitonin-salmon in the refrigerator. However, keep it from freezing.

Precautions While Using calcitonin

Your doctor should check your progress at regular visits to make sure that calcitonin does not cause unwanted effects.

If you are using calcitonin for hypercalcemia (too much calcium in the blood), your doctor may want you to follow a low-calcium diet. If you have any questions about this, check with your doctor.

calcitonin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Rare

• Skin rash or hives

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Diarrhea


• flushing or redness of face, ears, hands, or feet


• loss of appetite


• nausea or vomiting


• pain, redness, soreness, or swelling at place of injection


• stomach pain

Less common

• Increased frequency of urination

Rare

• Chills


• dizziness


• headache


• pressure in chest


• stuffy nose


• tenderness or tingling of hands or feet


• trouble in breathing


• weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: calcitonin Parenteral side effects (in more detail)

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products.

More calcitonin Parenteral resources

• Calcitonin Parenteral Side Effects (in more detail)
• Calcitonin Parenteral Use in Pregnancy & Breastfeeding
• Calcitonin Parenteral Drug Interactions
• Calcitonin Parenteral Support Group
• 2 Reviews for Calcitonin Parenteral - Add your own review/rating

Compare calcitonin Parenteral with other medications

• Hypercalcemia
• Osteogenesis Imperfecta
• Osteoporosis
• Paget's Disease

Nitisinone

Pronunciation: nye-TISS-ih-known
Generic Name: Nitisinone
Brand Name: Orfadin

Nitisinone is used for:

Treating hereditary tyrosinemia type 1 (HT-1), a genetic metabolism disorder. Nitisinone is used in combination with dietary restriction of tyrosine and phenylalanine.

Nitisinone is a 4-hydroxyphenylpyruvate dioxygenase inhibitor. It works by blocking the breakdown of tyrosine. This helps to reduce the amount of toxic byproducts in the body produced by the breakdown of tyrosine.

Do NOT use Nitisinone if:

• you are allergic to any ingredient in Nitisinone

Contact your doctor or health care provider right away if any of these apply to you.

Before using Nitisinone:

Some medical conditions may interact with Nitisinone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have any other metabolism disorders (eg, porphyria)

Some MEDICINES MAY INTERACT with Nitisinone. However, no specific interactions with Nitisinone are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Nitisinone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Nitisinone:

Use Nitisinone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Nitisinone on an empty stomach at least 1 hour before eating.


• If you have difficulty swallowing the capsule, it may be opened and the contents sprinkled into a small amount of water, formula, or applesauce immediately before use. Do not store the mixture for use at a later time.


• If you miss a dose of Nitisinone, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Nitisinone.

Important safety information:

• It is important to follow the dietary plan provided by your doctor in order to avoid the risk of serious side effects from Nitisinone.


• Diabetes patients - Nitisinone may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.


• LAB TESTS, including platelet and white blood cell counts, vision tests, liver function tests, and blood phosphate or tyrosine levels, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.


• PREGNANCY and BREAST-FEEDING: It is unknown if Nitisinone can cause harm to the fetus. If you think you may be pregnant, discuss with your doctor the benefits and risks of using Nitisinone during pregnancy. It is unknown if Nitisinone is excreted in breast milk. If you are or will be breast-feeding while you are using Nitisinone, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Nitisinone:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; blue skin or nails; dark urine; eye problems (eg, redness, swelling, burning, vision changes, light sensitivity, pain); fever, chills, or persistent sore throat; seizures; severe headache; skin lesions; stomach pain; unusual bruising or bleeding; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Nitisinone side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include eye problems (eg, redness, swelling, burning, vision changes, light sensitivity, pain); skin lesions.

Proper storage of Nitisinone:

Store Nitisinone in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C). Keep Nitisinone out of the reach of children and away from pets.

General information:

• If you have any questions about Nitisinone, please talk with your doctor, pharmacist, or other health care provider.


• Nitisinone is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Nitisinone. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Nitisinone resources

• Nitisinone Side Effects (in more detail)
• Nitisinone Use in Pregnancy & Breastfeeding
• Nitisinone Support Group
• 0 Reviews · Be the first to review/rate this drug

• Nitisinone Professional Patient Advice (Wolters Kluwer)


• nitisinone Concise Consumer Information (Cerner Multum)


• nitisinone Advanced Consumer (Micromedex) - Includes Dosage Information


• Orfadin Prescribing Information (FDA)

Johnson's Baby Cream

Pronunciation: dye-METH-i-kone
Generic Name: Dimethicone
Brand Name: Examples include Aveeno Moisturizing Lotion and Johnson's Baby Cream

Johnson's Baby Cream is used for:

Treating or preventing dry, itchy skin or minor skin irritations.

This product is an emollient. It works by moisturizing the skin.

Do NOT use Johnson's Baby Cream if:

• you are allergic to any ingredient in Johnson's Baby Cream

Contact your doctor or health care provider right away if any of these apply to you.

Before using Johnson's Baby Cream:

Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have an open wound, serious burn, or damaged, broken, or irritated skin

Some MEDICINES MAY INTERACT with Johnson's Baby Cream. However, no specific interactions with Johnson's Baby Cream are known at this time.

Ask your health care provider if Johnson's Baby Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Johnson's Baby Cream:

Use Johnson's Baby Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Johnson's Baby Cream is for external use only. Do not get Johnson's Baby Cream in your eyes, nose, or mouth. If you get Johnson's Baby Cream in your eyes, rinse immediately with cool tap water.


• Wash your hands before and after using Johnson's Baby Cream unless your hands are a part of the treated area.


• Wash and completely dry the affected area. Apply only enough of Johnson's Baby Cream to completely cover the affected area and gently rub in until it is evenly distributed.


• Do not wrap or bandage the treated area unless directed to do so by your doctor.


• If you miss using Johnson's Baby Cream for 1 or more days, there is no cause for concern. If your doctor recommended that you use it, try to remember every day.

Ask your health care provider any questions you may have about how to use Johnson's Baby Cream.

Important safety information:

• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Johnson's Baby Cream while you are pregnant. If you are or will be breast-feeding while you use Johnson's Baby Cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Johnson's Baby Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild itching, burning, or stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe or persistent itching, burning, or stinging; skin irritation; worsening dryness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Johnson's Baby side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Johnson's Baby Cream:

Store Johnson's Baby Cream at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not freeze. Keep Johnson's Baby Cream out of the reach of children and away from pets.

General information:

• If you have any questions about Johnson's Baby Cream, please talk with your doctor, pharmacist, or other health care provider.


• Johnson's Baby Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Johnson's Baby Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Johnson's Baby resources

• Johnson's Baby Side Effects (in more detail)
• Johnson's Baby Use in Pregnancy & Breastfeeding
• Johnson's Baby Support Group
• 0 Reviews for Johnson's Baby - Add your own review/rating

Compare Johnson's Baby with other medications

• Dry Skin

salicylic acid and sodium thiosulfate topical

Generic Name: salicylic acid and sodium thiosulfate topical (sal ah SILL ik AH sid and SEW dee um thigh oh SULL fate)

Brand names: Versiclear, Exoderm

What is salicylic acid and sodium thiosulfate topical?

Sodium thiosulfate is an antifungal agent. Sodium thiosulfate decreases the growth of fungus on the skin.

Salicylic acid is used with sodium thiosulfate to increase the absorption of sodium thiosulfate into the skin.

Sodium thiosulfate and salicylic acid topical is used in the treatment of tinea versicolor, a fungal infection of the skin that usually appears as white patches on the skin.

Salicylic acid and sodium thiosulfate topical may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about salicylic acid and sodium thiosulfate topical?

Stop using salicylic acid and sodium thiosulfate topical and contact your healthcare provider if you develop new or worsening signs of skin irritation. Do not use other topical products on the affected area unless otherwise directed by your doctor. They may interfere with the effects or absorption of salicylic acid and sodium thiosulfate topical. Do not cover the area with bandages or dressings after applying salicylic acid and sodium thiosulfate topical, unless otherwise directed by your doctor. Doing so could cause too much medicine to be absorbed by the body and could be harmful.

What should I discuss with my healthcare provider before using salicylic acid and sodium thiosulfate topical?

Do not use salicylic acid and sodium thiosulfate topical without first talking to your doctor if you have an allergy to sulfa products. You may not be able to use salicylic acid and sodium thiosulfate topical, or you may require special monitoring during treatment.

Do not apply salicylic acid and sodium thiosulfate topical to large areas of open, broken, burned, or infected skin without first talking to your doctor. Large areas of damaged skin may allow more medicine to be absorbed by the body, possibly resulting in side effects.

It is not known whether salicylic acid and sodium thiosulfate topical will be harmful to an unborn baby. Do not use salicylic acid and sodium thiosulfate topical without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether sodium sulfacetamide passes into breast milk. Do not use salicylic acid and sodium thiosulfate topical without first talking to your doctor if you are breast-feeding a baby.

How should I use salicylic acid and sodium thiosulfate topical?

Use salicylic acid and sodium thiosulfate topical exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash the hands before and after applying this medication, unless it is being used to treat a hand condition.

Thoroughly wash, rinse, and dry the affected areas before application of this medication.

Shake the lotion well before use. Apply a thin film of the lotion to the affected areas as directed by your doctor. Do not allow this medication to get into the eyes. If it does, rinse the eyes thoroughly with water. If irritation persists, contact your doctor. Do not cover the area with bandages or dressings after applying salicylic acid and sodium thiosulfate topical, unless otherwise directed by your doctor. Doing so could cause too much medicine to be absorbed by the body and could be harmful.

It is important to use sodium sulfacetamide regularly to get the most benefit. Use the medication for the full amount of time prescribed by your doctor. Symptoms may improve before the infection is fully treated.

Store salicylic acid and sodium thiosulfate topical at room temperature away from moisture and heat.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and apply only the next regularly scheduled dose.

What happens if I overdose?

An overdose of salicylic acid and sodium thiosulfate topical is unlikely to threaten life. If an overdose is suspected or if the medication has been ingested, call a poison control center or an emergency room for advice.

What should I avoid while using salicylic acid and sodium thiosulfate topical?

Do not use other topical products on the affected area unless otherwise directed by your doctor. They may interfere with the effects or absorption of salicylic acid and sodium thiosulfate topical. Do not cover the area with bandages or dressings after applying salicylic acid and sodium thiosulfate topical, unless otherwise directed by your doctor. Doing so could cause too much medicine to be absorbed by the body and could be harmful.

Salicylic acid and sodium thiosulfate topical side effects

Stop using salicylic acid and sodium thiosulfate topical and contact your healthcare provider if you develop new or worsening signs of skin irritation. Serious side effects are not likely to occur with the use of salicylic acid and sodium thiosulfate topical. If you experience a rare, but serious allergic reaction (shortness of breath; closing of the throat; swelling of the lips, face, or tongue; or hives), stop using salicylic acid and sodium thiosulfate topical and seek emergency medical attention or contact your doctor immediately.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect salicylic acid and sodium thiosulfate topical?

Do not use other topical products on the affected area unless otherwise directed by your doctor. They may interfere with the effects or absorption of salicylic acid and sodium thiosulfate topical.

Drugs other than those listed here may also interact with salicylic acid and sodium thiosulfate topical. Talk to your doctor and pharmacist before taking or using any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

More salicylic acid and sodium thiosulfate topical resources

• Salicylic acid and sodium thiosulfate topical Use in Pregnancy & Breastfeeding
• Salicylic acid and sodium thiosulfate topical Drug Interactions
• Salicylic acid and sodium thiosulfate topical Support Group
• 0 Reviews for Salicylic acid and sodium thiosulfate - Add your own review/rating

Compare salicylic acid and sodium thiosulfate topical with other medications

• Tinea Versicolor

Where can I get more information?

• Your pharmacist has additional information about salicylic acid and sodium thiosulfate topical written for health professionals that you may read.

Hydrocortone

Generic Name: hydrocortisone (oral) (hye droe KOR ti sone)

Brand Names: Cortef, Hydrocortone

What is hydrocortisone?

Hydrocortisone is in a class of drugs called steroids. Hydrocortisone prevents the release of substances in the body that cause inflammation.

Hydrocortisone is used to treat many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.

Hydrocortisone may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about hydrocortisone?

You should not use this medication if you are allergic to hydrocortisone, or if you have a fungal infection anywhere in your body.

Before taking hydrocortisone, tell your doctor about all of your medical conditions, and about all other medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids.

Your steroid medication needs may change if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you during treatment.

Steroid medication can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Do not receive a "live" vaccine while you are taking hydrocortisone. Vaccines may not work as well while you are taking a steroid.

Do not stop using hydrocortisone suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication. Carry an ID card or wear a medical alert bracelet stating that you are taking a steroid, in case of emergency.

What should I discuss with my healthcare provider before taking hydrocortisone?

You should not use this medication if you are allergic to hydrocortisone, or if you have a fungal infection anywhere in your body.

Steroid medication can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Before taking this medication, tell your doctor about any illness or infection you have had within the past several weeks.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take hydrocortisone:

• 
  

  liver disease (such as cirrhosis);

  
  


• 
  

  kidney disease;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  diabetes;

  
  


• 
  

  a history of malaria;

  
  


• 
  

  tuberculosis;

  
  


• 
  

  osteoporosis;

  
  


• 
  

  a muscle disorder such as myasthenia gravis;

  
  


• 
  

  glaucoma or cataracts;

  
  


• 
  

  herpes infection of the eyes;

  
  


• 
  

  stomach ulcers, ulcerative colitis, or diverticulitis;

  
  


• 
  

  depression or mental illness;

  
  


• 
  

  congestive heart failure; or

  
  


• 
  

  high blood pressure

  
  

FDA pregnancy category C. It is not known whether hydrocortisone is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Hydrocortisone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Steroids can affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using this medication.

How should I take hydrocortisone?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Your steroid medication needs may change if you have unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using hydrocortisone.

Do not stop using hydrocortisone suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication. Carry an ID card or wear a medical alert bracelet stating that you are taking a steroid, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking steroid medication. Store hydrocortisone at room temperature away from moisture and heat.

What happens if I miss a dose?

If you miss a dose or forget to take your medicine, contact your doctor or pharmacist for instructions.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine.

A single large dose of hydrocortisone is not expected to produce life-threatening symptoms. However, high doses taken over a long period of time may cause weight gain, roundness of the face, increased facial hair growth, bruising, swelling, and muscle pain or weakness.

What should I avoid while taking hydrocortisone?

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Do not receive a "live" vaccine while you are being treated with hydrocortisone. Vaccines may not work as well while you are taking a steroid.

Avoid drinking alcohol while you are taking hydrocortisone.

Hydrocortisone side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  problems with your vision;

  
  


• 
  

  swelling, rapid weight gain, feeling short of breath;

  
  


• 
  

  severe depression, unusual thoughts or behavior, seizure (convulsions);

  
  


• 
  

  bloody or tarry stools, coughing up blood;

  
  


• 
  

  pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate);

  
  


• 
  

  low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling); or

  
  


• 
  

  dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

  
  

Less serious side effects may include:

• 
  

  sleep problems (insomnia), mood changes;

  
  


• 
  

  acne, dry skin, thinning skin, bruising or discoloration;

  
  


• 
  

  slow wound healing;

  
  


• 
  

  increased sweating;

  
  


• 
  

  headache, dizziness, spinning sensation;

  
  


• 
  

  nausea, stomach pain, bloating; or

  
  


• 
  

  changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hydrocortisone?

There are many other medicines that can interact with steroids. Below is only a partial list of these medicines:

• 
  

  aspirin (taken on a daily basis or at high doses);

  
  


• 
  

  a diuretic (water pill);

  
  


• 
  

  a blood thinner such as warfarin (Coumadin);

  
  


• 
  

  cyclosporine (Gengraf, Neoral, Sandimmune);

  
  


• 
  

  insulin or diabetes medications you take by mouth;

  
  


• 
  

  ketoconazole (Nizoral);

  
  


• 
  

  rifampin (Rifadin, Rifater, Rifamate, Rimactane); or

  
  


• 
  

  seizure medications such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton).

  
  

This list is not complete and there may be other drugs that can interact with hydrocortisone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Hydrocortone resources

• Hydrocortone Side Effects (in more detail)
• Hydrocortone Use in Pregnancy & Breastfeeding
• Drug Images
• Hydrocortone Drug Interactions
• Hydrocortone Support Group
• 0 Reviews for Hydrocortone - Add your own review/rating

• Hydrocortisone Professional Patient Advice (Wolters Kluwer)


• Hydrocortisone Prescribing Information (FDA)


• Hydrocortisone Monograph (AHFS DI)


• A-Hydrocort Prescribing Information (FDA)


• Colocort Prescribing Information (FDA)


• Colocort Enema MedFacts Consumer Leaflet (Wolters Kluwer)


• Cortef Prescribing Information (FDA)


• Cortef MedFacts Consumer Leaflet (Wolters Kluwer)


• Cortef Advanced Consumer (Micromedex) - Includes Dosage Information


• Cortifoam Prescribing Information (FDA)


• Cortifoam Foam MedFacts Consumer Leaflet (Wolters Kluwer)


• Hydrocortisone Buteprate topical Monograph (AHFS DI)


• Solu-Cortef Prescribing Information (FDA)


• Solu-Cortef Solution MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Hydrocortone with other medications

• Addison's Disease
• Adrenocortical Insufficiency
• Asthma, acute
• Inflammatory Bowel Disease
• Inflammatory Conditions
• Shock

Where can I get more information?

• Your pharmacist can provide more information about hydrocortisone.

See also: Hydrocortone side effects (in more detail)

Apexicon

Generic Name: diflorasone (Topical application route)

dye-FLOR-a-sone dye-AS-e-tate

Commonly used brand name(s)

In the U.S.

• Apexicon


• Apexicon E


• Maxiflor


• Psorcon


• Psorcon E

In Canada

• Florone


• Flutone

Available Dosage Forms:

• Ointment


• Cream

Therapeutic Class: Corticosteroid, Strong

Pharmacologic Class: Diflorasone

Uses For Apexicon

Diflorasone topical is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. This medicine is a corticosteroid (cortisone-like medicine or steroid).

This medicine is available only with your doctor's prescription.

Before Using Apexicon

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of diflorasone topical in the pediatric population. However, because of this medicine's toxicity, it should be used with caution. Children may absorb large amounts through the skin, which can cause serious side effects. If your child is using this medicine, follow your doctor's instructions very carefully. For the cream form, safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of diflorasone topical in geriatric patients.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Cushing's syndrome (adrenal gland disorder) or


• Diabetes or


• Hyperglycemia (high blood sugar) or


• Intracranial hypertension (increased pressure in the head)—Use with caution. May make these conditions worse.

• Infection of the skin at or near the place of application or


• Large sores, broken skin, or severe skin injury at the place of application—The chance of side effects may be increased.

• Perioral dermatitis (skin problem) or


• Rosacea (skin problem)—The cream should not be used in patients with these conditions.

Proper Use of diflorasone

This section provides information on the proper use of a number of products that contain diflorasone. It may not be specific to Apexicon. Please read with care.

It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects or skin irritation.

This medicine is for use on the skin only. Do not get it in your eyes. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away with water.

This medicine should only be used for skin conditions that your doctor is treating. Check with your doctor before using it for other conditions, especially if you think that a skin infection may be present. This medicine should not be used to treat certain kinds of skin infections or conditions, such as severe burns.

Do not use the topical cream on the face, groin, or underarms unless directed to do so by your doctor.

To use:

• Wash your hands with soap and water before and after using this medicine.


• Apply a thin layer of this medicine to the affected area of the skin. Rub it in gently.


• Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.


• If the medicine is applied to the diaper area of an infant, do not use tight-fitting diapers or plastic pants unless directed to do so by your doctor.


• If your doctor ordered an occlusive dressing or airtight covering to be applied over the medicine, make sure you know how to apply it. Occlusive dressings increase the amount of medicine absorbed through your skin, so use them only as directed. If you have any questions about this, check with your doctor.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For redness, itching, and swelling of the skin:
  
  • For topical dosage form (cream):
    
    • Adults—Apply to the affected area of the skin two times per day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For topical dosage form (ointment):
    
    • Adults—Apply to the affected area of the skin one to three times per day.
    
    
    • Children—Apply to the affected area of the skin one to three times per day.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Apexicon

It is very important that your doctor check the progress of you or your child at regular visits for any unwanted effects that may be caused by this medicine.

If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. The risk is greater for children and patients who use large amounts for a long time. Talk to your doctor right away if you or your child have more than one of these symptoms while you are using this medicine: blurred vision; dizziness or fainting; a fast, irregular, or pounding heartbeat; increased thirst or urination; irritability; or unusual tiredness or weakness.

Stop using this medicine and check with your doctor right away if you or your child have a skin rash, burning, stinging, swelling, or irritation on the skin.

Do not use cosmetics or other skin care products on the treated areas.

Apexicon Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• Blistering, burning, crusting, dryness, or flaking of the skin


• irritation


• itching, scaling, severe redness, soreness, or swelling of the skin


• redness and scaling around the mouth


• thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (e.g. between the fingers)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Acne or pimples


• burning and itching of the skin with pinhead-sized red blisters


• burning, itching, and pain in hairy areas, or pus at the root of the hair


• increased hair growth on the forehead, back, arms, and legs


• lightening of normal skin color


• lightening of treated areas of dark skin


• reddish purple lines on the arms, face, legs, trunk, or groin


• softening of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Apexicon side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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