Read PLR Articles Directory Louisiana: May 2012

Wednesday, 30 May 2012

Azor

Pronunciation: am-LOE-di-peen/Ol-me-SAR-tan
Generic Name: Amlodipine/Olmesartan
Brand Name: Azor

Azor may cause birth defects, or fetal or newborn death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away.

Azor is used for:

Treating high blood pressure. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.

Azor is a calcium channel blocker and angiotensin II receptor blocker combination. It works by relaxing the blood vessels.

Do NOT use Azor if:

you are allergic to any ingredient in Azor

you are pregnant

Contact your doctor or health care provider right away if any of these apply to you.

Before using Azor:

Some medical conditions may interact with Azor. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are a woman of childbearing age

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you are dehydrated, have low blood volume or blood electrolyte problems (eg, high blood potassium levels, low blood sodium levels), or are on a low-salt (sodium) diet

if you have a history of gallbladder, liver, or kidney problems; low blood pressure; blood vessel problems; or heart problems (eg, heart failure, angina, narrowing of heart blood vessels)

if you have a history of a stroke or heart attack

if you have diabetes and you are also taking aliskiren

if you are on dialysis or will be having surgery

if you are taking another medicine for blood pressure or heart problems

Some MEDICINES MAY INTERACT with Azor. Tell your health care provider if you are taking any other medicines, especially any of the following:

Diuretics (eg, furosemide, hydrochlorothiazide) or sildenafil because the risk of low blood pressure may be increased

Aliskiren, potassium-sparing diuretics (eg, triamterene), or potassium supplements because the risk of high blood potassium levels may be increased

ACE inhibitors (eg, lisinopril) because the risk of kidney problems and high blood potassium levels may be increase

Azole antifungals (eg, itraconazole, ketoconazole), diltiazem, HIV protease inhibitors (eg, ritonavir), or vasopressin receptor antagonists (eg, conivaptan) because they may increase the risk of Azor's side effects

Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, celecoxib, ibuprofen) because they may decrease Azor's effectiveness and the risk of serious kidney problems may be increased

Lithium or simvastatin because the risk of their side effects may be increased by Azor

This may not be a complete list of all interactions that may occur. Ask your health care provider if Azor may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Azor:

Use Azor as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Azor by mouth with or without food.

Take Azor on a regular schedule to get the most benefit from it. Taking Azor at the same time each day will help you remember to take it.

Continue to take Azor even if you feel well. Do not miss any doses.

If you miss a dose of Azor, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Azor.

Important safety information:

Azor may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Azor with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Azor may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

It may take up to 2 weeks to get the full benefit from Azor. Do not stop using Azor without checking with your doctor.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

Check with your doctor before you use a salt substitute or a product that has potassium in it.

If vomiting, diarrhea, or excessive sweating occur, you will need to take care not to become dehydrated. This could increase your risk of low blood pressure. Contact your doctor for instructions.

Tell your doctor or dentist that you take Azor before you receive any medical or dental care, emergency care, or surgery.

Talk with your doctor or pharmacist about all of your blood pressure medicines and how to use them. Do not start, stop, or change the dose of any blood pressure medicine unless your doctor tells you to.

Lab tests, including blood pressure, kidney function, and blood electrolyte levels, may be performed while you use Azor. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Azor with caution in the ELDERLY; they may be more sensitive to its effects.

Azor should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

PREGNANCY and BREAST-FEEDING: Azor may cause birth defects or fetal or newborn death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. It is not known if Azor is found in breast milk. Do not breast-feed while taking Azor.

Possible side effects of Azor:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; flushing.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); change in the amount of urine produced; chest pain; fainting; fast or irregular heartbeat; light-headedness; numbness of an arm or leg; severe or persistent dizziness; severe or persistent muscle pain or aches; shortness of breath; sudden, severe headache or vomiting; sudden, unexplained weight gain; sudden vision changes; swelling of the feet, ankles, or hands; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Azor side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; fast or slow heartbeat; severe dizziness or light-headedness.

Proper storage of Azor:

Store Azor at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Azor out of the reach of children and away from pets.

General information:

If you have any questions about Azor, please talk with your doctor, pharmacist, or other health care provider.

Azor is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Azor. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Azor resources

Azor Side Effects (in more detail)
Azor Use in Pregnancy & Breastfeeding
Drug Images
Azor Drug Interactions
Azor Support Group
34 Reviews for Azor - Add your own review/rating

Azor Prescribing Information (FDA)

Azor Advanced Consumer (Micromedex) - Includes Dosage Information

Azor Consumer Overview

Compare Azor with other medications

High Blood Pressure

Sunday, 27 May 2012

Paroxetine Mesylate

Pronunciation: par-OX-e-teen MES-i-late
Generic Name: Paroxetine Mesylate
Brand Name: Pexeva

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using Paroxetine Mesylate outweigh the risks.

Families and caregivers must closely watch patients who take Paroxetine Mesylate. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.

Paroxetine Mesylate is used for:

Treating depression, obsessive-compulsive disorder (OCD), panic disorder, or generalized anxiety disorder (GAD). It may also be used for other conditions as determined by your doctor.

Paroxetine Mesylate is a selective serotonin reuptake inhibitor (SSRI). It works by restoring the balance of serotonin, a natural substance in the brain, which helps to improve certain mood problems.

Do NOT use Paroxetine Mesylate if:

you are allergic to any ingredient in Paroxetine Mesylate

you are taking or have taken linezolid, methylene blue, a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), selegiline, or St. John's wort within the last 14 days

you are taking a fenfluramine derivative (eg, dexfenfluramine), nefazodone, pimozide, a serotonin-norepinephrine reuptake inhibitor (SNRI) (eg, venlafaxine), another SSRI (eg, fluoxetine), sibutramine, thioridazine, or tryptophan

Contact your doctor or health care provider right away if any of these apply to you.

Video: Treatment for Depression

Treatments for depression are getting better everyday and there are things you can start doing right away.

Before using Paroxetine Mesylate:

Some medical conditions may interact with Paroxetine Mesylate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you or a family member has a history of bipolar disorder (manic-depression), other mental or mood problems, suicidal thoughts or attempts, or alcohol or substance abuse

if you have a history of seizures, heart problems, liver problems, severe kidney problems, stomach or bowel bleeding, narrow-angle glaucoma, diabetes, or metabolism problems

if you are dehydrated, have low blood sodium levels, or drink alcohol

if you will be having electroconvulsive therapy (ECT)

Some MEDICINES MAY INTERACT with Paroxetine Mesylate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anorexiants (eg, phentermine), cimetidine, fenfluramine derivatives (eg, dexfenfluramine), fentanyl, linezolid, lithium, MAOIs (eg, phenelzine), methylene blue, metoclopramide, nefazodone, selegiline, serotonin 5-HT₁ receptor agonists (eg, sumatriptan), sibutramine, SNRIs (eg, venlafaxine), another SSRI (eg, fluoxetine), St. John's wort, tramadol, trazodone, or tryptophan because severe side effects, such as a reaction that may include fever, rigid muscles, blood pressure changes, mental changes, confusion, irritability, agitation, delirium, or coma, may occur

Anticoagulants (eg, warfarin), aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of bleeding, including stomach bleeding, may be increased

Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood sodium levels may be increased

Antiarrhythmics (eg, flecainide, propafenone, quinidine), astemizole, phenothiazines (eg, chlorpromazine, thioridazine), or terfenadine because severe heart problems, including irregular heartbeat, may occur

Cyproheptadine, HIV protease inhibitors (eg, ritonavir), phenobarbital, or phenytoin because they may decrease Paroxetine Mesylate's effectiveness

Aripiprazole, atomoxetine, clozapine, fluoxetine, pimozide, procyclidine, risperidone, theophylline, or tricyclic antidepressants (eg, amitriptyline) because the risk of their side effects may be increased by Paroxetine Mesylate

Digoxin or tamoxifen because their effectiveness may be decreased by Paroxetine Mesylate

This may not be a complete list of all interactions that may occur. Ask your health care provider if Paroxetine Mesylate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Paroxetine Mesylate:

Use Paroxetine Mesylate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Paroxetine Mesylate comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Paroxetine Mesylate refilled.

Take Paroxetine Mesylate by mouth with or without food.

Swallow Paroxetine Mesylate whole. Do not crush or chew before swallowing.

Taking Paroxetine Mesylate at the same time each day will help you remember to take it.

Continue to take Paroxetine Mesylate even if you feel well. Do not miss any doses.

Do not suddenly stop taking Paroxetine Mesylate without checking with your doctor. Side effects may occur. They may include mental or mood changes, numbness or tingling of the skin, ringing in the ears, dizziness, confusion, headache, trouble sleeping, or unusual tiredness. You will be closely monitored when you start Paroxetine Mesylate and whenever a change in dose is made.

If you miss a dose of Paroxetine Mesylate, take it as soon as possible. If it almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Paroxetine Mesylate.

Important safety information:

Paroxetine Mesylate may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Paroxetine Mesylate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Paroxetine Mesylate; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Do not drink alcohol while you are taking Paroxetine Mesylate.

Several weeks may pass before your symptoms get better. Do NOT take more than the recommended dose, change your dose, or use Paroxetine Mesylate for longer than prescribed without checking with your doctor.

Children, teenagers, and young adults who take Paroxetine Mesylate may be at increased risk of suicidal thoughts or actions. Closely watch all patients who take Paroxetine Mesylate. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

If your doctor tells you to stop taking Paroxetine Mesylate, you will need to wait for several weeks before beginning to take certain other medicines (eg, MAOIs, nefazodone). Ask your doctor when you should start to take your new medicines after you have stopped taking Paroxetine Mesylate.

Paroxetine Mesylate may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.

Serotonin syndrome is a possibly fatal syndrome that can be caused by Paroxetine Mesylate. Your risk may be greater if you take Paroxetine Mesylate with certain other medicines (eg, "triptans," MAOIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.

Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Paroxetine Mesylate. Your risk may be greater if Paroxetine Mesylate is used with certain other medicines called antipsychotics (eg, aripiprazole, risperidone). Symptoms may be similar to serotonin syndrome and may include fever, rigid muscles, blood pressure changes, and mental changes. Contact your doctor at once if you have any of these symptoms.

Paroxetine Mesylate may affect fertility in some men. Discuss any questions or concerns with your doctor.

Use Paroxetine Mesylate with caution in the ELDERLY; they may be more sensitive to its effects, especially low blood sodium levels.

Caution is advised when using Paroxetine Mesylate in CHILDREN; they may be more sensitive to its effects, especially increased risk of suicidal thoughts or actions.

Paroxetine Mesylate should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

Paroxetine Mesylate may cause weight changes. CHILDREN and teenagers may need regular weight and growth checks while they take Paroxetine Mesylate.

PREGNANCY and BREAST-FEEDING: Paroxetine Mesylate may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Paroxetine Mesylate while you are pregnant. Paroxetine Mesylate is found in breast milk. If you are or will be breast-feeding while you take Paroxetine Mesylate, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Paroxetine Mesylate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; blurred vision; constipation; decreased sexual desire or ability; diarrhea; dizziness; drowsiness; dry mouth; gas; increased sweating; increased urination; loss of appetite; nausea; nervousness; numbness or tingling of the skin; stomach upset; trouble sleeping; weakness; yawning.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bizarre behavior; black or bloody stools; chest pain; confusion; decreased concentration; decreased coordination; exaggerated reflexes; fainting; fast or irregular heartbeat; fever, chills, or sore throat; hallucinations; memory loss; new or worsening mental or mood changes (eg, agitation, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated feeling of well-being, restlessness, or inability to sit still); persistent or severe ringing in the ears; persistent, painful erection; red, swollen, blistered, or peeling skin; seizures; severe or persistent anxiety or trouble sleeping; severe or persistent headache or dizziness; significant weight loss; stomach pain; suicidal thoughts or attempts; tremor; unusual bone pain or unexplained swelling, tenderness, or bruising; unusual bruising or bleeding; unusual weakness; vision changes; worsening of depression.

See also: Paroxetine Mesylate side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include coma; confusion; dilated pupils; fainting; fast, slow, or irregular heartbeat; inability to urinate; seizures; severe muscle pain; severe or persistent dizziness, drowsiness, nausea, or vomiting; tremor; yellowing of the eyes or skin.

Proper storage of Paroxetine Mesylate:

Store Paroxetine Mesylate at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Paroxetine Mesylate out of the reach of children and away from pets.

General information:

If you have any questions about Paroxetine Mesylate, please talk with your doctor, pharmacist, or other health care provider.

Paroxetine Mesylate is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is summary only. It does not contain all information about Paroxetine Mesylate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Paroxetine Mesylate resources

Paroxetine Mesylate Side Effects (in more detail)
Paroxetine Mesylate Dosage
Paroxetine Mesylate Use in Pregnancy & Breastfeeding
Drug Images
Paroxetine Mesylate Drug Interactions
Paroxetine Mesylate Support Group
242 Reviews for Paroxetine Mesylate - Add your own review/rating

Paroxetine Prescribing Information (FDA)

Paroxetine Professional Patient Advice (Wolters Kluwer)

Paroxetine Hydrochloride Monograph (AHFS DI)

Paxil Prescribing Information (FDA)

Paxil Consumer Overview

Paxil CR Prescribing Information (FDA)

Pexeva Prescribing Information (FDA)

paroxetine Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Paroxetine Mesylate with other medications

Anxiety
Anxiety and Stress
Body Dysmorphic Disorder
Depression
Dysautonomia
Dysthymia
Generalized Anxiety Disorder
Hot Flashes
Obsessive Compulsive Disorder
Panic Disorder
Post Traumatic Stress Disorder
Postpartum Depression
Premenstrual Dysphoric Disorder
Social Anxiety Disorder
Trichotillomania
Vulvodynia

Saturday, 26 May 2012

Stridex Maximum Strength Pads

Pronunciation: sal-ih-SILL-ik AS-id
Generic Name: Salicylic Acid
Brand Name: Examples include Propa pH Acne Med Cleansing and Stridex Maximum Strength

Stridex Maximum Strength Pads are used for:

Treating acne. It may also be used for other conditions as determined by your doctor.

Stridex Maximum Strength Pads are a topical salicylate. It works by causing the skin to swell, soften, and then slough or peel in areas where it is applied.

Do NOT use Stridex Maximum Strength Pads if:

you are allergic to any ingredient in Stridex Maximum Strength Pads

Contact your doctor or health care provider right away if any of these apply to you.

Before using Stridex Maximum Strength Pads:

Some medical conditions may interact with Stridex Maximum Strength Pads. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to aspirin or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen, celecoxib)

if you have liver or kidney problems, a skin infection, skin irritation, diabetes, or poor blood circulation

Some MEDICINES MAY INTERACT with Stridex Maximum Strength Pads. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants, (eg, heparin, warfarin), aspirin, methotrexate, or sulfonylureas (eg, glipizide) because the risk of side effects may be increased by Stridex Maximum Strength Pads

This may not be a complete list of all interactions that may occur. Ask your health care provider if Stridex Maximum Strength Pads may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Stridex Maximum Strength Pads:

Use Stridex Maximum Strength Pads as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Wash and completely dry the affected area. Use a pad to cleanse and cover the affected area with a thin layer of medicine. Do not leave pad on the skin. Unless your hands are being treated, be sure to wash your hands after each use.

If you miss a dose of Stridex Maximum Strength Pads, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Stridex Maximum Strength Pads.

Important safety information:

Stridex Maximum Strength Pads are for external use only. Avoid getting Stridex Maximum Strength Pads in your eyes, nose, or mouth, or on the genitals. If contact with your eyes occurs, flush with water for 15 minutes. Do not inhale the vapors of Stridex Maximum Strength Pads.

Overuse of topical products may worsen your condition.

Do not use Stridex Maximum Strength Pads longer or more often than recommended by your doctor or on the package label.

Check with your doctor before use if you have a condition that covers a large area of the body.

Be sure to apply Stridex Maximum Strength Pads only to the affected area and not to normal healthy skin.

Do not use Stridex Maximum Strength Pads on skin that is irritated, infected, or reddened.

Do not use Stridex Maximum Strength Pads on open skin wounds, moles, birthmarks, genital warts, warts on the face, or warts growing hair.

Do not use any other medicines or drying products on your skin unless your doctor instructs you otherwise.

Stridex Maximum Strength Pads may interfere with certain lab test results. Make sure your doctor and lab personnel know you are using Stridex Maximum Strength Pads.

Stridex Maximum Strength Pads are extremely flammable. Do not store or use Stridex Maximum Strength Pads near a fire or other open flame.

Stridex Maximum Strength Pads may be harmful if swallowed. If you may have taken Stridex Maximum Strength Pads by mouth, contact your local poison control center or emergency room immediately.

Stridex Maximum Strength Pads contains a salicylate, which has been linked to Reye syndrome. Do not use Stridex Maximum Strength Pads on children or teenagers during or after chickenpox, flu, or other viral infections without checking with your doctor or pharmacist.

Caution is advised when using Stridex Maximum Strength Pads in CHILDREN because they may be more sensitive to its effects.

PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Stridex Maximum Strength Pads during pregnancy. It is unknown if Stridex Maximum Strength Pads are excreted in breast milk. Do not breast-feed while you are using Stridex Maximum Strength Pads.

Possible side effects of Stridex Maximum Strength Pads:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dry, peeling, red, or scaling skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe irritation.

See also: Stridex Maximum Strength side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; diarrhea; dizziness; loss of appetite; loss of hearing; mental disturbances; nausea; rapid or difficult breathing; ringing in the ears; seizures; sluggishness; vomiting; yellowing of the skin or eyes.

Proper storage of Stridex Maximum Strength Pads:

Store Stridex Maximum Strength Pads at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not freeze. Do not store in the bathroom. Keep Stridex Maximum Strength Pads out of the reach of children and away from pets.

General information:

If you have any questions about Stridex Maximum Strength Pads, please talk with your doctor, pharmacist, or other health care provider.

Stridex Maximum Strength Pads are to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Stridex Maximum Strength Pads. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Stridex Maximum Strength resources

Stridex Maximum Strength Side Effects (in more detail)
Stridex Maximum Strength Use in Pregnancy & Breastfeeding
Stridex Maximum Strength Drug Interactions
Stridex Maximum Strength Support Group
0 Reviews for Stridex Maximum Strength - Add your own review/rating

Compare Stridex Maximum Strength with other medications

Acne
Dermatological Disorders

Thursday, 24 May 2012

Sudafed PE

Pronunciation: FEN-il-EF-rin
Generic Name: Phenylephrine
Brand Name: Examples include Contac-D and Sudafed PE

Sudafed PE is used for:

Relieving congestion due to colds, flu, hay fever, and other allergies. It may also be used for other conditions as determined by your doctor.

Sudafed PE is a decongestant. It works by reducing swelling and constricting blood vessels in the nasal passages, allowing you to breathe more easily.

Do NOT use Sudafed PE if:

you are allergic to any ingredient in Sudafed PE

you have had an unusual reaction (eg, dizziness, weakness, tremors, irregular heartbeat) to another sympathomimetic medicine (eg, pseudoephedrine)

you are taking furazolidone or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) in the last 14 days

you have severe high blood pressure, severe heart blood vessel disease, fast heartbeat, or severe heart problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Sudafed PE:

Some medical conditions may interact with Sudafed PE. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of glaucoma or increased pressure in the eye, enlarged prostate gland or other prostate problems, heart problems, diabetes, high blood pressure, blood vessel problems, adrenal gland problems, overactive thyroid, seizures, or stroke

Some MEDICINES MAY INTERACT with Sudafed PE. Tell your health care provider if you are taking any other medicines, especially any of the following:

Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), furazolidone, indomethacin, methyldopa, or MAOIs (eg, phenelzine) because they may increase the risk of Sudafed PE's side effects

Tricyclic antidepressants (eg, amitriptyline) because they may decrease Sudafed PE's effectiveness

Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased

Bromocriptine because the risk of its side effects may be increased by Sudafed PE

Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Sudafed PE

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sudafed PE may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Sudafed PE:

Use Sudafed PE as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Sudafed PE by mouth with or without food.

If you miss a dose of Sudafed PE and are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Sudafed PE.

Important safety information:

Sudafed PE may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Sudafed PE with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

If your symptoms do not get better within 7 days or if you develop a high fever, check with your doctor.

Sudafed PE has phenylephrine in it. Before you start any new medicine, check the label to see if it has phenylephrine or pseudoephedrine in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take diet or appetite control medicines while you are taking Sudafed PE.

If you have trouble sleeping, ask your pharmacist or doctor about the best time to take Sudafed PE.

Tell your doctor or dentist that you take Sudafed PE before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Sudafed PE may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Use Sudafed PE with caution in the ELDERLY; they may be more sensitive to its effects.

Caution is advised when using Sudafed PE in CHILDREN; they may be more sensitive to its effects.

Different brands of Sudafed PE may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.

Sudafed PE should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sudafed PE while you are pregnant. Sudafed PE is found in breast milk. Do not breast-feed while taking Sudafed PE.

Possible side effects of Sudafed PE:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; nausea; nervousness; restlessness; sleeplessness; stomach irritation.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fast or irregular heartbeat; hallucinations; seizures; tremor; trouble urinating.

See also: Sudafed PE side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room right away. Symptoms may include confusion; hallucinations; irregular or unusually slow or rapid heartbeat; rapid breathing; seizures.

Proper storage of Sudafed PE:

Store Sudafed PE at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Sudafed PE out of the reach of children and away from pets.

General information:

If you have any questions about Sudafed PE, please talk with your doctor, pharmacist, or other health care provider.

Sudafed PE is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Sudafed PE. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Sudafed PE resources

Sudafed PE Side Effects (in more detail)
Sudafed PE Use in Pregnancy & Breastfeeding
Sudafed PE Drug Interactions
Sudafed PE Support Group
0 Reviews for Sudafed PE - Add your own review/rating

Sudafed PE Consumer Overview

Neo-Synephrine Nasal Advanced Consumer (Micromedex) - Includes Dosage Information

Phenylephrine Hydrochloride Monograph (AHFS DI)

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Nasal Congestion

Infant Glycerol

Infant Glycerol may be available in the countries listed below.

Ingredient matches for Infant Glycerol

Glycerol

Glycerol is reported as an ingredient of Infant Glycerol in the following countries:

Oman

International Drug Name Search

Symbyax

Generic Name: fluoxetine and olanzapine (floo OX eh teen and oh LAN za peen)

Brand Names: Symbyax

What is fluoxetine and olanzapine?

Fluoxetine is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs).

Olanzapine is an antipsychotic medication. These drugs affect chemicals in the brain.

The combination of fluoxetine and olanzapine is used to treat depression caused by bipolar disorder (manic depression). Fluoxetine and olanzapine is also used to treat depression after at least 2 other medications have been tried without successful treatment of symptoms.

Fluoxetine and olanzapine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about fluoxetine and olanzapine?

This medication is not for use in psychotic conditions related to dementia. Olanzapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. Do not use this medication together with pimozide (Orap) or thioridazine (Mellaril), or if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you become pregnant while taking fluoxetine and olanzapine, do not stop taking it without your doctor's advice.

What should I discuss with my healthcare provider before taking fluoxetine and olanzapine?

You must wait at least 14 days after stopping an MAOI before you can take fluoxetine and olanzapine. After you stop taking fluoxetine and olanzapine, you must wait at least 5 weeks before you start taking thioridazine (Mellaril) or an MAOI.

Video: Treatment for Depression

Treatments for depression are getting better everyday and there are things you can start doing right away.

To make sure you can safely take fluoxetine and olanzapine, tell your doctor if you have any of these other conditions:

liver disease;

heart disease, high or low blood pressure, or a history of heart attack or stroke;

diabetes, high cholesterol or triglycerides;

seizures or epilepsy;

narrow-angle glaucoma;

paralytic ileus (a stomach disorder);

breast cancer;

enlarged prostate; or

a history of drug abuse or suicidal thoughts.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking fluoxetine and olanzapine, do not stop taking it without your doctor's advice.

FDA pregnancy category C. An SSRI antidepressant may cause serious lung problems in a newborn if you take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. Fluoxetine and olanzapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking this medication. Do not give this medication to anyone under 18 years old without medical advice.

How should I take fluoxetine and olanzapine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Fluoxetine and olanzapine can be taken with or without food. Try to take the medicine at the same time each day.

It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 4 weeks of treatment.

Olanzapine can cause high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis while you are taking olanzapine.

Store at room temperature away from moisture and heat.

See also: Symbyax dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include some of the serious side effects listed in this medication guide.

What should I avoid while taking fluoxetine and olanzapine?

Drinking alcohol can increase certain side effects of fluoxetine and olanzapine. Fluoxetine and olanzapine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Fluoxetine and olanzapine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have a serious side effect such as:

sudden and severe headache, chest pain, numbness, and problems with vision, speech, or balance;

increased thirst, frequent urination, excessive hunger, or weakness;

agitation, hallucinations, fever, fast heart rate, overactive reflexes, vomiting, diarrhea, loss of coordination;

very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;

jerky muscle movements you cannot control, seizure (convulsions);

feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;

flu symptoms, easy bruising, sores in your mouth and throat; or

seizure (convulsions);

nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

dry mouth, increased appetite, weight gain;

feeling drowsy or tired;

blurred vision; or

swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect fluoxetine and olanzapine?

Ask your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with fluoxetine and olanzapine may cause you to bruise or bleed easily.

Before using fluoxetine and olanzapine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures or anxiety). They can add to sleepiness caused by fluoxetine and olanzapine.

Tell your doctor about all other medicines you use, especially:

vinblastine (Velban);

heart rhythm or blood pressure medication;

tryptophan (sometimes called L-tryptophan);

lithium, clozapine (Clozaril, Fazaclo), haloperidol (Haldol);

phenytoin (Dilantin), carbamazepine (Carbatrol, Tegretol);

a blood thinner such as warfarin (Coumadin, Jantoven);

theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl, and others);

medicine to treat Parkinson's disease, such as bromocriptine (Parlodel), pergolide (Permax), pramipexole (Mirapex), ropinorole (Requip), or cabergoline (Cabaser);

almotriptan (Axert), frovatriptan (Frova), sumatriptan (Imitrex, Treximet), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig); or

any other antidepressants, especially another form of fluoxetine or olanzapine such as Prozac, Prozac Weekly, Sarafem, or Zyprexa.

This list is not complete and other drugs may interact with fluoxetine and olanzapine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Symbyax resources

Symbyax Side Effects (in more detail)
Symbyax Dosage
Symbyax Use in Pregnancy & Breastfeeding
Drug Images
Symbyax Drug Interactions
Symbyax Support Group
25 Reviews for Symbyax - Add your own review/rating

Symbyax Prescribing Information (FDA)

Symbyax Advanced Consumer (Micromedex) - Includes Dosage Information

Symbyax MedFacts Consumer Leaflet (Wolters Kluwer)

Symbyax Consumer Overview

Compare Symbyax with other medications

Bipolar Disorder
Depression

Where can I get more information?

Your pharmacist can provide more information about fluoxetine and olanzapine.

See also: Symbyax side effects (in more detail)

Karvol Decongestant Capsules (Reckitt Benckiser Healthcare (UK) Ltd)

1. Name Of The Medicinal Product

Karvol Decongestant Capsules

2. Qualitative And Quantitative Composition

Active ingredient	mg/capsule
Chlorobutanol	2.25
Levomenthol	35.55
Pine Oil Sylvestris	9.0
Terpineol	66.6
Thymol	3.15
Pumilio Pine Oil	103.05

3. Pharmaceutical Form

Capsule

4. Clinical Particulars

4.1 Therapeutic Indications

For the symptomatic relief of colds in the head and the symptomatic rapid relief of nasal congestion.

4.2 Posology And Method Of Administration

For inhalation.

Snip tip off capsule carefully, pointing top downwards and away from the face.

For Older Children and Adults:

Nightime: Dab contents of one capsule on to bedding or handkerchief nearby but avoiding direct skin contact.

Daytime: Squeeze contents of one capsule on to a tissue or into a pint of hot water and inhale the vapour freely.

For Young Children:

Dab contents of one capsule on to a handkerchief tied down securely in the vicinity, but out of reach of the child.

Elderly:

There is no need to modify the administration of this preparation for use by the elderly.

Children Under 3 Months:

Not recommended for children under 3 months of age.

4.3 Contraindications

Children under 3 months of age.

4.4 Special Warnings And Precautions For Use

Avoid contact with the eyes and prolonged contact with the skin.

If symptoms persist consult your doctor.

Keep all medicines out of the reach of children.

Do not take internally.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

No clinically significant interactions known.

4.6 Pregnancy And Lactation

The safety of Karvol in pregnancy and lactation has not been established, but is not expected to constitute a hazard.

4.7 Effects On Ability To Drive And Use Machines

No adverse effects known.

4.8 Undesirable Effects

No side effects would be anticipated.

4.9 Overdose

Symptoms of overdose may included nausea, vomiting, colic, headache, dizziness, a feeling of warmth, delirium, muscle twitching, epileptiform convulsions, depressed respiration, CNS depression and coma. Initial treatment consists of emptying the stomach by lavage and aspiration. Administer a saline laxative such as sodium sulphate and activated charcoal by mouth. Convulsions may be controlled with diazepam or thiopental sodium.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Menthol, Chlorobutanol, Pine Oil and Terpineol are volatile substances and are thought to produce an irritant effect on the respiratory tract, possibly via a nasal/pulmonary arc.

5.2 Pharmacokinetic Properties

Not applicable.

5.3 Preclinical Safety Data

Not applicable.

6. Pharmaceutical Particulars

6.1 List Of Excipients

PEG – 20 Stearate

Cinnamon Oil

Polysorbate 80 (Tween 80)

Polyethylene Glycol 400 (Macrogol)

Triacetin

6.2 Incompatibilities

Not applicable.

6.3 Shelf Life

36 months.

6.4 Special Precautions For Storage

Do not store above 25°C.

6.5 Nature And Contents Of Container

A capsule contained in a 200 or 250 Fm PVC or 200 or 250 Fm PVC/40 gsm PVDC blister, heat sealed to aluminium foil. Packs of either 1, 2(stencilled card), 4, 5, 6, 8, 10, 12, 14, 15, 16, 18, 20, 22, 24, 25, 26, 28, 30, 32 or 36 capsules in a printed carton.

An amber glass bottle having a thermoset plastic screw cap containing 500 capsules.

Not all pack sizes may be marketed.

6.6 Special Precautions For Disposal And Other Handling

Not applicable.

7. Marketing Authorisation Holder

Crookes Healthcare Limited

1 Thane Road West

Nottingham

NG2 3AA

United Kingdom

8. Marketing Authorisation Number(S)

PL 0327/5914R

9. Date Of First Authorisation/Renewal Of The Authorisation

16 June 1989 / 24 February 1995

10. Date Of Revision Of The Text

11/09/2007

Wednesday, 23 May 2012

Sulfacetamide

Class: Antibacterials
ATC Class: S01AB
VA Class: OP210
CAS Number: 6209-17-2
Brands: Bleph 10, Blephamide, FML-S

Introduction

Sulfonamide anti-infective.¹⁰⁷

Uses for Sulfacetamide

Bacterial Ophthalmic Infections

Treatment of conjunctivitis, corneal ulcers, and other superficial infections of the eye caused by susceptible Staphylococcus aureus, Streptococcus pneumoniae, viridans streptococci, Haemophilus influenzae, Enterobacter, Escherichia coli, and Klebsiella.¹⁰⁷ ¹⁰⁸ ^f

Used alone or in fixed combination with topical corticosteroids (e.g., fluorometholone, prednisolone) when such combination therapy is indicated.^b ^c ^e ^g

Ineffective for treatment of infections caused by Neisseria, Serratia marcescens, or Pseudomonas aeruginosa.¹⁰⁸ ^b ^c ^e ^f ^g Consider that staphylococci frequently are resistant to sulfonamides.¹⁰⁸ ^b ^c ^e ^f ^g

Chlamydial Ophthalmic Infections

Has been used as an adjunct to systemic anti-infectives for treatment of trachoma; ¹⁰⁷ ¹⁰⁸ ^f however, systemic anti-infectives are recommended.¹⁰⁶ No data to support use of topical anti-infectives in conjunction with systemic therapy.¹⁰⁶

Sulfacetamide Dosage and Administration

Administration

Ophthalmic Administration

Apply topically to the eye(s) as an ophthalmic ointment, solution, or suspension.¹⁰⁷ ¹⁰⁸ ^b ^c ^e ^f ^g

Not for injection;¹⁰⁷ ¹⁰⁸ ^b ^c ^e ^f do not inject subconjunctivally or instill directly into the anterior chamber of the eye.^g

Avoid contamination of the tip of the container.^b ^c ^e ^f ^g

Shake suspension well prior to use.^b ^g

Dosage

Available as sulfacetamide sodium; dosage expressed in terms of the salt.^f

Available as fixed combinations containing sulfacetamide sodium and prednisolone acetate, prednisolone sodium phosphate, or fluorometholone; dosage expressed in terms of the salt.^b ^c ^e ^g

Pediatric Patients

Bacterial Ophthalmic Infections

Sulfacetamide 10%

Ophthalmic Solution

Children ≥2 months of age: Initially, 1 or 2 drops into the conjunctival sac of the affected eye(s) every 2–3 hours.^f Reduce dosing frequency as infection improves.^f Usual duration of treatment is 7–10 days.^f

Sulfacetamide 10% and Fluorometholone 0.1%

Ophthalmic Suspension

Children ≥2 years of age: 1 drop into the conjunctival sac of the affected eye(s) 4 times daily.^g Reduce dosing frequency as infection improves.^g

If improvement does not occur after 2 days, reevaluate the patient.^g Do not discontinue prematurely.^g

When discontinuing therapy in chronic conditions, gradually taper dosing frequency.^g

Sulfacetamide 10% and Prednisolone Acetate 0.2%

Ophthalmic Ointment

Children ≥6 years of age: Apply a 1.25-cm ribbon into the conjunctival sac of the affected eye(s) 3 or 4 times daily during the day and once or twice during the night.^c Reduce dosing frequency as infection improves.^c

If improvement does not occur after 2 days, reevaluate the patient.^b ^c Do not discontinue prematurely.^b ^c

When discontinuing therapy in chronic conditions, gradually taper dosing frequency.^b ^c

Ophthalmic Suspension

Children ≥6 years of age: 2 drops into the conjunctival sac of the affected eye(s) every 4 hours during the day and at bedtime.^b Reduce dosing frequency as infection improves.^b

If improvement does not occur after 2 days, reevaluate the patient.^b ^c Do not discontinue prematurely.^b ^c

When discontinuing therapy in chronic conditions, gradually taper dosing frequency.^b ^c

Sulfacetamide 10% and Prednisolone Sodium Phosphate 0.25%

Ophthalmic Solution

Children ≥6 years of age: 2 drops into the affected eye(s) every 4 hours.^e Reduce dosing frequency as infection improves.^e

If improvement does not occur after 2 days, reevaluate the patient.^e Do not discontinue prematurely.^e

When discontinuing therapy in chronic conditions, gradually taper dosing frequency.^e

Chlamydial Ophthalmic Infections

Trachoma

Ophthalmic Solution

Sulfacetamide 10% in children ≥2 months of age: 2 drops into the conjunctival sac of the affected eye(s) every 2 hours in conjunction with systemic anti-infectives.^f

Adults

Bacterial Ophthalmic Infections

Sulfacetamide 10%

Ophthalmic Solution

Initially, 1 or 2 drops of solution into the conjunctival sac of the affected eye(s) every 2–3 hours.^f Reduce dosing frequency as infection improves.^f Usual duration of treatment is 7–10 days.^f

Sulfacetamide 10% and Fluorometholone 0.1%

Ophthalmic Suspension

1 drop into the conjunctival sac of the affected eye(s) 4 times daily.^g Reduce dosing frequency as infection improves.^g

If improvement does not occur after 2 days, reevaluate the patient.^g Do not discontinue prematurely.^g

When discontinuing therapy in chronic conditions, gradually taper dosing frequency.^g

Sulfacetamide 10% and Prednisolone Acetate 0.2%

Ophthalmic Ointment

Apply a 1.25-cm ribbon into the conjunctival sac of the affected eye(s) 3 or 4 times daily during the day and once or twice during the night.^c Reduce dosing frequency as infection improves.^c

If improvement does not occur after 2 days, reevaluate the patient.^b ^c Do not discontinue prematurely.^b ^c

When discontinuing therapy in chronic conditions, gradually taper dosing frequency.^b ^c

Ophthalmic Suspension

2 drops into the conjunctival sac of the affected eye(s) every 4 hours during the day and at bedtime.^b Reduce dosing frequency as infection improves.^b

If improvement does not occur after 2 days, reevaluate the patient.^b ^c Do not discontinue prematurely.^b ^c

When discontinuing therapy in chronic conditions, gradually taper dosing frequency.^b ^c

Sulfacetamide 10% and Prednisolone Sodium Phosphate 0.25%

Ophthalmic Solution

2 drops into the affected eye(s) every 4 hours.^e Reduce dosing frequency as infection improves.^e

If improvement does not occur after 2 days, reevaluate the patient.^e Do not discontinue prematurely.^e

When discontinuing therapy in chronic conditions, gradually taper dosing frequency.^e

Chlamydial Ophthalmic Infections

Trachoma

Ophthalmic Solution

Sulfacetamide 10%: 2 drops into the conjunctival sac of the affected eye(s) every 2 hours, in conjunction with systemic anti-infectives.^f

Special Populations

No special population dosage recommendations at this time.^a ^b ^c ^e ^f ^g

Cautions for Sulfacetamide

Contraindications

Known or suspected hypersensitivity to sulfonamides or to any ingredient in the formulation.¹⁰⁷ ¹⁰⁸ ^b ^c ^e ^f ^g

Warnings/Precautions

Warnings

Severe Reactions

Severe, fatal reactions to sulfonamides have occurred rarely, including dermatologic reactions, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, or other blood dyscrasias.¹⁰⁷ ¹⁰⁸ ^f ^g

Adverse reactions reported with systemic sulfonamides could occur with topical application.¹⁰⁷

Sensitivity Reactions

Hypersensitivity

Topical application of sulfonamides may produce sensitization and preclude later systemic use of these drugs.¹⁰⁷ ^a ^f ^g In addition, patients who have been sensitized by systemic sulfonamide administration may exhibit hypersensitivity reactions following topical application of the drugs.¹⁰⁷ ^a ^f ^g

Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported rarely following topical application in individuals with a history of hypersensitivity to systemic sulfonamides.¹⁰⁷ ¹⁰⁸ ^f ^g

Cross-sensitivity occurs among the various sulfonamides.¹⁰⁸ ^f

Discontinue sulfonamide therapy immediately at the first sign of hypersensitivity, rash, or other serious reaction.¹⁰⁷ ¹⁰⁸ ^f ^g

General Precautions

Superinfection

Use of sulfonamides may result in the overgrowth of nonsusceptible organisms, including fungi.¹⁰⁷ ¹⁰⁸ ^f ^g Bacterial and fungal corneal ulcers have developed during use of ophthalmic sulfonamide preparations.¹⁰⁸

Discontinue drug and institute appropriate therapy if superinfection occurs.¹⁰⁷

Ophthalmic Ointments

Ophthalmic ointments may delay corneal healing.^c

Use of Fixed Combinations Containing Corticosteroids

Concomitant topical corticosteroids may mask clinical signs of bacterial, fungal, or viral infections; prevent recognition of ineffectiveness of the antibiotic; or suppress hypersensitivity reactions to sulfonamides or other ingredients in the formulation.¹⁰⁷ ^c

When sulfacetamide is used in fixed combination with a corticosteroid, consider the cautions, precautions, and contraindications associated with EENT corticosteroids.^b ^c ^e ^g

Specific Populations

Pregnancy

Category C.¹⁰⁸ ^f

Lactation

Systemically absorbed sulfonamides can cause kernicterus in neonates and infants.¹⁰⁸ ^f ^g Discontinue nursing or the drug.¹⁰⁸ ^f ^g

Pediatric Use

Safety and efficacy of ophthalmic sulfacetamide sodium not established in infants <2 months of age.¹⁰⁷ ¹⁰⁸ ^f

Safety and efficacy of fixed-combination ophthalmic sulfacetamide and prednisolone not established in children <6 years of age.^b ^c ^e

Safety and efficacy of fixed-combination ophthalmic sulfacetamide and fluorometholone not established in children <2 years of age.^g

Geriatric Use

No substantial differences in safety and efficacy relative to younger adults.^g

Common Adverse Effects

Local irritation, transient stinging or burning.¹⁰⁷ ^a ^f

Interactions for Sulfacetamide

Specific Drugs

Drug	Interaction	Comments
Anesthetics, local (p-aminobenzoic acid related	Possible antagonism of action of sulfonamides¹⁰⁷
Gentamicin	In vitro antagonism^b ^c ^e	Do not use concomitantly^b ^c ^e

Sulfacetamide Pharmacokinetics

Absorption

Extent

Sulfonamides do not appear to be appreciably absorbed from mucous membranes.¹⁰⁷

Distribution

Extent

Systemic sulfonamides cross the placenta and are distributed into human milk in low concentrations.^h

Stability

Storage

Ophthalmic

Sulfonamide preparations darken on prolonged standing and exposure to heat and light.^b ^e ^f Discard preparations that have darkened; yellow discoloration does not affect activity.^b ^e ^f

Ointment

Sulfacetamide sodium and prednisolone acetate: Tightly closed containers at 15–25°C.^c

Solution

Sulfacetamide sodium: 8–25°C; protect from light and freezing.^f

Sulfacetamide sodium and prednisolone sodium phosphate: 15–25°C; protect from light.^e

Suspension

Sulfacetamide sodium and fluorometholone: 15–30°C; protect from light and freezing.^g

Sulfacetamide sodium and prednisolone acetate: Upright position at 8–24°C; protect from light and freezing.^b

Compatibility

For information on systemic interactions resulting from concomitant use, see Interactions.

Ophthalmic

Ointment or Solution

Sulfacetamide sodium is incompatible with preparations containing silver.¹⁰⁷ ¹⁰⁸ ^f

Precipitation may occur if zinc sulfate is added to sulfacetamide sodium solutions, depending on the concentration of each drug.¹⁰⁷

Actions and SpectrumActions

Usually bacteriostatic,^f but may be bactericidal at very high concentrations.¹⁰⁷ ¹⁰⁸

Sulfonamides interfere with utilization of aminobenzoic or aminobenzoic glutamic acids by susceptible organisms, thus inhibiting biosynthesis of folic acid which is essential for growth.¹⁰⁷ ^a ^f Only organisms that synthesize their own folic acid are inhibited by sulfonamides; animal cells and bacteria that are capable of utilizing folic acid precursors or preformed folic acid are not affected.¹⁰⁷

Antibacterial activity is decreased in the presence of blood or purulent exudates containing p-aminobenzoic acid.¹⁰⁷ ¹⁰⁸ ^a ^f

Spectrum of activity includes some aerobic gram-positive and -negative bacteria.¹⁰⁷ ^a

Gram-positive aerobic bacteria: Active against S. aureus, S. pneumoniae, and viridans streptococci.¹⁰⁷ ¹⁰⁸ ^a ^f ^g Many staphylococci are resistant.¹⁰⁷ ¹⁰⁸ ^g

Gram-negative aerobic bacteria: Active against H. influenzae, Enterobacter, E. coli, and Klebsiella.¹⁰⁸ ^a ^f ^g

Cross-resistance usually occurs among the various sulfonamides.¹⁰⁷ ^a ^f

Advice to Patients

Importance of not touching tip of container to eye, eyelid, or any other surface.¹⁰⁸ ^b ^c ^e ^f ^g Advise patient to keep container tightly closed when not in use.^g

Importance of discontinuing use and contacting clinician at first sign of hypersensitivity, increase in discharge, or if pain or swelling worsen.¹⁰⁸ ^b ^c ^f

Advise patient not to share the drug with any other person.^c ^g

Importance of removing soft contact lenses prior to administering preparations containing benzalkonium chloride and of delaying reinsertion of the lenses for ≥5 minutes after administration.^b ⁱ

Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs.^f

Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.^f

Importance of informing patients of other important precautionary information. (See Cautions.)

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Sulfacetamide Sodium
Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Bulk	Powder
Ophthalmic	Ointment	10%*	Sulfacetamide Sodium Ophthalmic Ointment	Fougera
	Solution	10%*	Bleph 10 (with benzalkonium chloride)	Allergan
			Sulfacetamide Sodium Ophthalmic Solution	Bausch & Lomb, Falcon

Sulfacetamide Sodium and Prednisolone Acetate
Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Ophthalmic	Ointment	10% Sulfacetamide Sodium and Prednisolone Acetate 0.2%	Blephamide (with phenylmercuric acetate)	Allergan
	Suspension	10% Sulfacetamide Sodium and Prednisolone Acetate 0.2%	Blephamide (with benzalkonium chloride)	Allergan

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Other Sulfacetamide Sodium Combinations
Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Ophthalmic	Solution	10% with 0.25% Prednisolone Sodium Phosphate (0.23% of prednisolone phosphate)*	Sulfacetamide Sodium and Prednisolone Sodium Phosphate Ophthalmic Solution	Bausch & Lomb, Falcon
Ophthalmic	Suspension	10% with Fluorometholone 0.1%	FML-S (with benzalkonium chloride and povidone)	Allergan

Comparative Pricing

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

Bleph-10 10% Solution (ALLERGAN): 5/$27.99 or 15/$61.97

Blephamide 10-0.2% Suspension (ALLERGAN): 10/$95.99 or 30/$275.97

Blephamide 10-0.2% Suspension (ALLERGAN): 5/$67.99 or 15/$189.98

Blephamide S.O.P. 10-0.2% Ointment (ALLERGAN): 3/$68.99 or 10/$185.96

Sulfacetamide Sodium 10% Solution (FALCON PHARMACEUTICALS): 15/$12.99 or 30/$18.98

Sulfacetamide-Prednisolone 10-0.23% Solution (BAUSCH & LOMB): 10/$30.99 or 20/$53.97

Sulfacetamide-Prednisolone 10-0.23% Solution (BAUSCH & LOMB): 5/$21.99 or 15/$53.97

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

References

Only references cited for selected revisions after 1984 are available electronically.

101. Allergan, Inc. Bleph-10 (sulfacetamide sodium) ophthalmic ointment prescribing information. In: Physicians’ desk reference for ophthalmic medicines. 34th ed. Montvale, NJ: Thomson PDR; 2006:219-20.

102. Fougera. Sulfacetamide sodium ophthalmic ointment USP, 10% prescribing information. Melville, NY; 1998 Mar.

103. Falcon Pharmaceuticals, Ltd. Sulfacetamide sodium and prednisolone sodium phosphate ophthalmic solution. Fort Worth, TX; 2003 Nov.

104. Allergan. FML-S (fluorometholone and sulfacetamide sodium ophthalmic suspension, USP) 0.1%/10% prescribing information. In: Physicians’ desk reference for ophthalmic medicines. 34th ed. Montevale, NJ: Thomson PDR; 2006:226-7.

105. American Academy of Pediatrics. Red book: 2006 Report of the Committee on Infectious Diseases. 27th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2006;252-7.

106. American Academy of Ophthalmology. Preferred Practice Pattern: Conjunctivitis. 2003. From the American Academy of Ophthalmology website. Accessed 11 May 2006.

107. AHFS Drug Information 2003. McEvoy, GK, ed. Sulfonamides (ophthalmic). Bethesda, MD: American Society of Health-System Pharmacists; 2003:2613-4.

108. Akorn. AK-Sulf (sulfacetamide sodium) ophthalmic solution prescribing information. Buffalo Grove, IL: 2000 May.

109. Committee on Infectious Diseases, American Academy of Pediatrics. 2000 Red book: report of the Committee on Infectious Diseases. 25th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2000:210.

110. Anon. The choice of antibacterial drugs. Med Lett Drugs Ther. 2001; 43:69-78. [PubMed 11518876]

111. Allergan, Inc. Bleph-10 (sulfacetamide sodium) ophthalmic ointment prescribing information. Irvine, CA; 1993 Sept.

a. AHFS drug information 2008. McEvoy, GK, ed. Sulfacetamide sodium. Bethesda, MD: American Society of Health-System Pharmacists; 2008:2855-6.

b. Allergan, Inc. Blephamide (sulfacetamide sodium and prednisolone acetate, USP ophthalmic suspension) 10%/0.2% prescribing information. Irvine, CA; 2004 Jun.

c. Allergan, Inc. Blephamide (sulfacetamide sodium and prednisolone acetate ophthalmic ointment, USP) 10%/0.2% prescribing information. Irvine, CA; 2004 Sept.

e. Falcon Pharmaceuticals, Ltd. Sulfacetamide sodium and prednisolone sodium phosphate ophthalmic solution prescribing information. Fort Worth, TX; 2007 Jul.

f. Allergan, Inc. Bleph-10 (sulfacetamide sodium ophthalmic solution, USP) 10% prescribing information. Irvine, CA; 2005 Feb.

g. Allergan, Inc. FML-S (fluorometholone and sulfacetamide sodium ophthalmic suspension, USP) 0.1%/10% prescribing information. Irvine, CA; 2005 Feb.

h. Briggs CC, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation, 7th ed. Philadelphia, PA: Lippincott, Williams, & Wilkins; 2005: 1508-10.

i. Christensen MT, Barry JR, Turner FD. Five-minute removal of soft lenses prevents most absorption of a topical ophthalmic solution. CLAO J. 1998; 24:227-31. [PubMed 9800062]

More Sulfacetamide resources

Sulfacetamide Use in Pregnancy & Breastfeeding
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Sulfacetamide Support Group
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